Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800779 | 0.96 | XDH (0.47) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800677 | 0.95 | MCL1 (0.46) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL18800407 | 0.92 | F2 (0.49) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800472 | 0.92 | XDH (0.46) | MEN1KMT2ABTKXDHNPC1 | |
| SCHEMBL18800785 | 0.91 | MCL1 (0.50) | ALDH1A1MAPTLMNABTKXDH | |
| SCHEMBL18800645 | 0.91 | NPC1 (0.45) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800717 | 0.91 | BTK (0.45) | MEN1KMT2ABTKXDHNPC1 | |
| SCHEMBL18800806 | 0.90 | BTK (0.49) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL18800656 | 0.89 | BTK (0.55) | ALDH1A1MAPTBTKXDHNPC1 | |
| SCHEMBL16168183 | 0.89 | LTA4H (0.47) | BTKXDHNPC1RAB9AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |