Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL161482 | 0.99 | DGAT1 (0.54) | DGAT1KDRKITCNR1CDK8 | |
| SCHEMBL163752 | 0.87 | DGAT1 (0.58) | DGAT1KDRKITCNR1RIPK1 | |
| SCHEMBL12503669 | 0.86 | DGAT1 (0.51) | DGAT1KDRKITCNR1CDK8 | |
| SCHEMBL15022138 | 0.86 | DGAT1 (0.57) | DGAT1KDRKITCNR1TEK | |
| Hydrochloric Acid SCHEMBL163660 | 0.86 | DGAT1 (0.57) | DGAT1KDRKITCNR1RIPK1 | |
| SCHEMBL161878 | 0.83 | DGAT1 (0.52) | DGAT1KDRKITCNR1RIPK1 | |
| SCHEMBL160684 | 0.81 | DGAT1 (0.49) | DGAT1KDRKITCNR1CDK8 | |
| SCHEMBL161990 | 0.81 | DGAT1 (0.51) | DGAT1KDRKITCNR1RIPK1 | |
| Hydrochloric Acid SCHEMBL160270 | 0.81 | DGAT1 (0.57) | DGAT1KDRKITCNR1CDK8 | |
| SCHEMBL164633 | 0.79 | DGAT1 (0.50) | DGAT1KDRKITCNR1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |