Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 8/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL163660 | 0.99 | DGAT1 (0.57) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL12503659 | 0.88 | DGAT1 (0.53) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL15021985 | 0.88 | DGAT1 (0.59) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL161687 | 0.87 | DGAT1 (0.55) | DGAT1NTRK1CNR1KDRKIT | |
| Hydrochloric Acid SCHEMBL161482 | 0.86 | DGAT1 (0.54) | DGAT1NTRK1CNR1KDRKIT | |
| SCHEMBL158731 | 0.85 | DGAT1 (0.54) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL159242 | 0.83 | DGAT1 (0.51) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL15022135 | 0.83 | DGAT1 (0.53) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL15022044 | 0.81 | DGAT1 (0.52) | DGAT1CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL160270 | 0.81 | DGAT1 (0.57) | DGAT1CNR1KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |