Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 8/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 8/20 | 0.68 |
| ▸ | RELA | Q04206 | 8/20 | 0.68 |
| ▸ | CXCL12 | P48061 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166082 | 0.93 | NFKB1 (0.70) | NFKB1NFKB2RELACXCL12MAPT | |
| SCHEMBL17583534 | 0.93 | NFKB1 (0.70) | NFKB1NFKB2RELACXCL12MAPT | |
| SCHEMBL16166213 | 0.87 | NFKB1 (0.63) | NFKB1NFKB2RELACXCL12MAPT | |
| SCHEMBL16166215 | 0.87 | NFKB1 (0.63) | NFKB1NFKB2RELACXCL12MAPT | |
| SCHEMBL14249291 | 0.87 | NFKB1 (0.78) | NFKB1NFKB2RELAMAPTPDE4D | |
| SCHEMBL14249292 | 0.87 | NFKB1 (0.78) | NFKB1NFKB2RELAMAPTPDE4D | |
| SCHEMBL31398714 | 0.86 | NFKB1 (0.83) | NFKB1NFKB2RELAMAPTCYP3A4 | |
| SCHEMBL16865561 | 0.77 | NFKB1 (0.54) | NFKB1NFKB2RELAABCG2 | |
| SCHEMBL16867645 | 0.74 | ABCG2 (0.56) | NFKB1NFKB2RELAMAPTCYP3A4 | |
| SCHEMBL31376173 | 0.71 | HIF1AN (0.59) | NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617213-B2 | Synthetic analogues of xanthohumol | UNIVERSITA' DI PISA (IT) | 2017-04-11 | — | — | US | disclosed |
| US-9617213-B2 | Synthetic analogues of xanthohumol | UNIVERSITA' DI PISA (IT) | 2017-04-11 | — | — | US | disclosed |
| US-20160075652-A1 | SYNTHETIC ANALOGUES OF XANTHOHUMOL | AZIENDA OSPEDALIERA DI REGGIO EMILIA ARCISPEDALE S. MARIA NUOVA IRCCS (IT) | 2016-03-17 | — | — | US | disclosed |
| WO-2014167481-A1 | SYNTHETIC ANALOGUES OF XANTHOHUMOL | UNIVERSITA' DI PISA (IT) | 2014-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075652-A1 | SYNTHETIC ANALOGUES OF XANTHOHUMOL | XDH, XPA, NR1H3 | NFKB1 2593/4885NFKB2 3043/4885RELA 3702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.