Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.65 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | ADA | P00813 | 1/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.44 |
| ▸ | ADK | P55263 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15759356 | 1.00 | ADORA2A (0.65) | ADORA2APRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL12151837 | 1.00 | ADORA2A (0.65) | ADORA2APRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL12758164 | 1.00 | ADORA2A (0.65) | ADORA2APRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL731182 | 1.00 | ADORA2A (0.65) | ADORA2APRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL12149498 | 1.00 | ADORA2A (0.65) | ADORA2APRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL24837545 | 1.00 | ADORA2A (0.65) | ADORA2APRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL18636317 | 1.00 | ADORA2A (0.65) | ADORA2APRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL13770320 | 0.91 | ADORA2A (0.53) | ADORA2APRMT5WDR77ADORA3ADK | |
| SCHEMBL14010191 | 0.89 | ADORA2A (0.51) | ADORA2APRMT5WDR77DOT1LADK | |
| SCHEMBL14036258 | 0.89 | ADORA2A (0.51) | ADORA2APRMT5WDR77DOT1LADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140309412-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE | IONIS PHARMACEUTICALS, INC. | 2014-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309412-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE | NSUN2, NSUN3, POLRMT | ADORA2A 416/4885PRMT5 436/4885WDR77 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.