Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 5/20 | 0.80 |
| ▸ | TYK2 | P29597 | 2/20 | 0.80 |
| ▸ | SYK | P43405 | 2/20 | 0.80 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.80 |
| ▸ | FES | P07332 | 1/20 | 0.80 |
| ▸ | FER | P16591 | 1/20 | 0.80 |
| ▸ | FRK | P42685 | 1/20 | 0.80 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18115380 | 0.91 | PIKFYVE (0.75) | PIKFYVETYK2SYKIRAK4FES | |
| SCHEMBL18121521 | 0.91 | PIKFYVE (0.75) | PIKFYVETYK2SYKIRAK4FES | |
| SCHEMBL18165044 | 0.90 | PIKFYVE (0.77) | PIKFYVETYK2SYKIRAK4FES | |
| Apilimod SCHEMBL29387519 | 0.89 | PIKFYVE (1.00) | PIKFYVETYK2SYKIRAK4FES | |
| Apilimod SCHEMBL29365634 | 0.89 | PIKFYVE (1.00) | PIKFYVETYK2SYKIRAK4FES | |
| Apilimod SCHEMBL29459498 | 0.89 | PIKFYVE (1.00) | PIKFYVETYK2SYKIRAK4FES | |
| Apilimod SCHEMBL426299 | 0.89 | PIKFYVE (1.00) | PIKFYVETYK2SYKIRAK4FES | |
| Apilimod SCHEMBL426300 | 0.89 | PIKFYVE (1.00) | PIKFYVETYK2SYKIRAK4FES | |
| SCHEMBL18115257 | 0.89 | PIKFYVE (0.84) | PIKFYVETYK2SYKIRAK4FES | |
| SCHEMBL18115352 | 0.89 | PIKFYVE (0.84) | PIKFYVETYK2SYKIRAK4FES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923557-B2 | Process for preparing trisubstituted pyrimidine compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-04-12 | — | — | US | disclosed |
| US-20060122209-A1 | Process for preparing trisubstituted pyrimidine compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122209-A1 | Process for preparing trisubstituted pyrimidine compounds | TYMS, NUDT1, TYMP | PIKFYVE 2300/4885TYK2 1701/4885SYK 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.