Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16880329 | 0.89 | GRM4 (0.47) | GRM4OPRL1 | |
| SCHEMBL30622028 | 0.83 | CHRM2 (0.48) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL370789 | 0.82 | FFAR2 (0.38) | SSTR4ALOX5APFEN1HTR1ASLC6A2 | |
| SCHEMBL11150188 | 0.79 | TDP1 (0.47) | SSTR4HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25347064 | 0.79 | ALOX5AP (0.41) | ALOX5APFEN1HTR2CHTR2BHTR3A | |
| SCHEMBL19171957 | 0.79 | ALOX5AP (0.46) | ALOX5APFEN1GRM4FFAR4PDE5A | |
| SCHEMBL760442 | 0.79 | HTR2C (0.45) | ALOX5APFEN1HTR1AHTR2AHTR2C | |
| SCHEMBL13257866 | 0.79 | SSTR4 (0.43) | SSTR4ALOX5APFEN1HTR1ASLC6A2 | |
| SCHEMBL28133771 | 0.78 | ALOX5AP (0.52) | ALOX5APFEN1FFAR4PDE5APDE4A | |
| SCHEMBL29007768 | 0.77 | CHRNA3 (0.64) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593431-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |
| EP-2593432-B1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | PFIZER LTD (GB) | 2014-10-22 | — | — | EP | disclosed |