Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011475 | 0.93 | TAAR1 (0.47) | TAAR1NPC1RAB9APOLB | |
| SCHEMBL16175720 | 0.93 | KMT2A (0.45) | KMT2ANPC1RAB9A | |
| SCHEMBL5012262 | 0.91 | NPC1 (0.43) | KMT2ATAAR1NPC1GAARAB9A | |
| SCHEMBL5014451 | 0.91 | TP53 (0.43) | KMT2ADRD2 | |
| SCHEMBL5011116 | 0.90 | ALDH1A1 (0.46) | KMT2ATAAR1NPC1GAARAB9A | |
| SCHEMBL5012838 | 0.90 | KMT2A (0.47) | KMT2ACYP1A2POLBCYP2C19 | |
| SCHEMBL5124305 | 0.84 | ALDH1A1 (0.46) | KMT2ADRD2SIGMAR1 | |
| SCHEMBL5012210 | 0.83 | ALDH1A1 (0.45) | KMT2A | |
| SCHEMBL16175653 | 0.83 | KMT2A (0.56) | KMT2AL3MBTL1 | |
| SCHEMBL5064863 | 0.83 | KMT2A (0.52) | KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |