Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5064863 | 0.96 | KMT2A (0.52) | KMT2AMCHR1SMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL16175692 | 0.95 | KMT2A (0.50) | KMT2ATP53MCHR1MEN1 | |
| SCHEMBL5012838 | 0.93 | KMT2A (0.47) | KMT2AATM | |
| SCHEMBL16175419 | 0.91 | KMT2A (0.47) | KMT2ATP53MEN1 | |
| SCHEMBL16175620 | 0.91 | KMT2A (0.47) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL16175753 | 0.90 | MCHR1 (0.47) | KMT2AMCHR1SMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL5011245 | 0.89 | KMT2A (0.48) | KMT2ATP53MEN1 | |
| SCHEMBL16175761 | 0.89 | KMT2A (0.48) | KMT2ATP53MCHR1SMN1; SMN2MEN1 | |
| SCHEMBL16175723 | 0.88 | KMT2A (0.47) | KMT2ATP53ATM | |
| SCHEMBL16175720 | 0.87 | KMT2A (0.45) | KMT2ATP53SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |