SCHEMBL5011245

SCHEMBL5011245

COc1cccc(C2=NOC3(CCN(OC(=O)NCc4ccc(C)cc4)CC3)C2)c1

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.48
ALDH1A1 P00352 1/20 0.47
GAA P10253 1/20 0.47
TSHR P16473 2/20 0.45
LMNA P02545 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C19 P33261 1/20 0.45
TP53 P04637 3/20 0.43
MAPT P10636 3/20 0.43
KDM4E B2RXH2 2/20 0.43
HPGD P15428 1/20 0.43
MEN1 O00255 1/20 0.42
KIT P10721 1/20 0.41
IGF1R P08069 1/20 0.40
ALK Q9UM73 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16175757 0.95 ALDH1A1 (0.53) KMT2AALDH1A1GAATSHRLMNA
SCHEMBL5012257 0.93 TSHR (0.53) KMT2AALDH1A1GAATSHRLMNA
SCHEMBL16175753 0.90 MCHR1 (0.47) KMT2AALDH1A1LMNACYP1A2CYP3A4
SCHEMBL16175653 0.89 KMT2A (0.56) KMT2ATP53MEN1
SCHEMBL16175692 0.88 KMT2A (0.50) KMT2AALDH1A1GAATP53KDM4E
SCHEMBL5131413 0.88 PKM (0.50) KMT2AALDH1A1GAATSHRLMNA
SCHEMBL16175620 0.88 KMT2A (0.47) KMT2AALDH1A1GAATSHRLMNA
SCHEMBL5011238 0.87 LMNA (0.41) KMT2AALDH1A1GAATSHRLMNA
SCHEMBL5015851 0.87 SMN1; SMN2 (0.44) KMT2AALDH1A1GAATSHRCYP1A2
SCHEMBL5064863 0.86 KMT2A (0.52) KMT2AALDH1A1TSHRLMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1888596-B1 SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS GRUENENTHAL GMBH (DE) 2014-10-22 EP claimed
EP-1888596-A1 SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS Grünenthal GmbH (DE) 2008-02-20 EP claimed
WO-2006122770-A1 SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS Grünenthal GmbH (DE) 2006-11-23 WO claimed
EP-1888596-B1 SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS GRUENENTHAL GMBH (DE) 2014-10-22 EP disclosed