Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175419 | 0.95 | KMT2A (0.47) | KMT2ATP53MEN1ALDH1A1GLA | |
| SCHEMBL16175653 | 0.95 | KMT2A (0.56) | KMT2ATP53MCHR1MEN1 | |
| SCHEMBL5064863 | 0.95 | KMT2A (0.52) | KMT2AMCHR1MEN1ALDH1A1 | |
| SCHEMBL16175753 | 0.94 | MCHR1 (0.47) | KMT2AMCHR1HRH3MEN1ALDH1A1 | |
| SCHEMBL16175761 | 0.94 | KMT2A (0.48) | KMT2ATP53MCHR1HRH3MEN1 | |
| SCHEMBL16175723 | 0.93 | KMT2A (0.47) | KMT2ATP53GAA | |
| SCHEMBL5011245 | 0.88 | KMT2A (0.48) | KMT2ATP53MEN1KDM4EALDH1A1 | |
| SCHEMBL5012838 | 0.88 | KMT2A (0.47) | KMT2A | |
| SCHEMBL16175732 | 0.86 | KMT2A (0.49) | KMT2AMCHR1HRH3MEN1ALDH1A1 | |
| SCHEMBL16175620 | 0.85 | KMT2A (0.47) | KMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |