Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16177977 | 0.85 | CHRNA7 (0.58) | NPC1RAB9AALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL16178763 | 0.85 | CHRNA7 (0.56) | HTTNPC1RAB9AALDH1A1CHRNA7 | |
| SCHEMBL13930758 | 0.83 | ALDH1A1 (0.48) | HTTRAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL16178418 | 0.81 | HTT (0.57) | HTTNPC1RAB9AALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL3713052 | 0.81 | POLB (0.58) | NPC1RAB9AALDH1A1LIMK2GAA | |
| SCHEMBL2399513 | 0.80 | HTT (0.78) | HTTNPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL782107 | 0.77 | CHRNA7 (0.83) | CHRNA7KCNH2 | |
| Hydrochloric Acid SCHEMBL780250 | 0.77 | KCNH2 (0.84) | CHRNA7KCNH2 | |
| SCHEMBL27979642 | 0.76 | HTT (0.89) | HTTNPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL16178483 | 0.75 | HTT (0.65) | HTTNPC1RAB9AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096614-B2 | Therapeutically active thiazolo-pyrimidine derivatives | UCB PHARMA SA (BE) | 2015-08-04 | — | — | US | disclosed |
| US-20140315885-A1 | Therapeutically Active Thiazolo-Pyrimidine Derivatives | UCB PHARMA SA (BE) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315885-A1 | Therapeutically Active Thiazolo-Pyrimidine Derivatives | TPMT, IFNG, IRF3 | HTT 2650/4885NPC1 1968/4885RAB9A 1399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.