Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.50 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14849638 | 0.79 | PTGDR2 (0.50) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL66549 | 0.79 | CDC7 (0.60) | CDC7DBF4MAPK14CCNE1CDK2 | |
| SCHEMBL12491310 | 0.78 | MAPK14 (0.45) | CDC7DBF4MAPK14CCNE1CDK2 | |
| SCHEMBL16180657 | 0.77 | MAPK14 (0.40) | CDC7DBF4MAPK14ALDH1A1KDM4E | |
| SCHEMBL1836488 | 0.72 | DYRK1A (0.58) | CDC7LRRK2MEN1KMT2ADYRK1A | |
| SCHEMBL29432628 | 0.72 | DYRK1A (0.58) | CDC7LRRK2MEN1KMT2ADYRK1A | |
| SCHEMBL11381340 | 0.71 | ADORA3 (0.50) | MEN1ALDH1A1KMT2AKDM4EGLA | |
| Bromide SCHEMBL5752578 | 0.70 | DYRK1A (0.56) | CDC7LRRK2MEN1KMT2ADYRK1A | |
| SCHEMBL16937936 | 0.70 | CDC7 (0.49) | CDC7DBF4MAPK14CCNE1CDK2 | |
| SCHEMBL14832763 | 0.70 | ALOX5 (0.41) | CDC7DBF4ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014172639-A1 | RAF KINASE INHIBITORS | RUGA CORPORATION (US) | 2014-10-23 | — | — | WO | disclosed |