Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10308881 | 0.84 | MTOR (0.42) | MTORNPC1ALDH1A1TSHRRAB9A | |
| SCHEMBL2935553 | 0.74 | — | — | |
| SCHEMBL18648152 | 0.74 | EGLN2 (0.44) | HTTNPC1EGLN2ALDH1A1HPGD | |
| SCHEMBL18730526 | 0.72 | MAPT (0.40) | HTTNPC1HPGDHSD17B10KDM4E | |
| Indole SCHEMBL6692522 | 0.70 | TRPA1 (0.42) | HTTMTORNPC1ALDH1A1HPGD | |
| SCHEMBL10195600 | 0.69 | NAMPT (0.49) | KITPIK3CA | |
| SCHEMBL15489049 | 0.68 | MTOR (0.39) | HTTMTORNPC1ALDH1A1HDAC1 | |
| SCHEMBL7118968 | 0.67 | ATM (0.36) | ALDH1A1SMN1; SMN2CYP1A2KIT | |
| SCHEMBL24185300 | 0.67 | NR1H2 (0.49) | NPC1ALDH1A1HPGDKDM4EHDAC1 | |
| SCHEMBL6996440 | 0.66 | CYP1A2 (0.33) | SMN1; SMN2CYP1A2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865726-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | ARRAY BIOPHARMA INC. (US) | 2014-10-21 | — | — | US | disclosed |