Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA4 | P22748 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861480 | 0.91 | PTGS2 (0.56) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL861064 | 0.88 | PTGS2 (0.57) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL861487 | 0.87 | PTGS2 (0.51) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL14731425 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL860836 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL861474 | 0.85 | CA12 (0.56) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL860837 | 0.85 | PTGS2 (0.50) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL860830 | 0.84 | CA12 (0.55) | PTGS2PTGS1HRH4CA12CA4 | |
| SCHEMBL861702 | 0.83 | CA12 (0.53) | PTGS2PTGS1HRH4CA12CA4 | |
| SCHEMBL13290390 | 0.83 | FOLH1 (0.47) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865130-B2 | Methods and compositions for diagnostic and therapeutic targeting of COX-2 | VANDERBILT UNIVERSITY (US) | 2014-10-21 | — | — | US | disclosed |