Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | TPMT | P51580 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30251221 | 0.89 | KDM4E (0.67) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL8911580 | 0.87 | PKM (0.58) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL15526194 | 0.87 | POLB (0.55) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL6394441 | 0.81 | PKM (0.55) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL11929030 | 0.80 | KDM4E (0.69) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL16168327 | 0.80 | HMGCR (0.54) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL12135968 | 0.79 | KDM4E (0.67) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL9576652 | 0.79 | KDM4E (0.67) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL12134840 | 0.78 | POLB (0.49) | KDM4EPOLBHSD17B10USP2PKM | |
| SCHEMBL9202476 | 0.78 | PKM (0.46) | KDM4EPOLBHSD17B10USP2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865708-B2 | Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-10-21 | — | — | US | disclosed |