Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13559344 | 0.98 | POLB (0.46) | POLBNPC1LTA4HALDH1A1GFER | |
| SCHEMBL13559350 | 0.87 | GAA (0.51) | POLBALDH1A1GFERSMN1; SMN2KDM4E | |
| SCHEMBL16181825 | 0.86 | GAA (0.56) | POLBALDH1A1GFERKDM4EL3MBTL1 | |
| SCHEMBL13559355 | 0.85 | KDM4E (0.40) | POLBALDH1A1GFERKDM4EL3MBTL1 | |
| SCHEMBL13559348 | 0.85 | SIGMAR1 (0.44) | ALDH1A1GFERKDM4EL3MBTL1MEN1 | |
| SCHEMBL13559336 | 0.85 | MEN1 (0.49) | POLBNPC1ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL16181808 | 0.85 | OPRM1 (0.43) | ALDH1A1GFERKDM4EL3MBTL1MEN1 | |
| SCHEMBL13559366 | 0.84 | CYP1A2 (0.41) | ALDH1A1GFERKDM4EL3MBTL1MEN1 | |
| SCHEMBL13559367 | 0.84 | KDM4E (0.39) | POLBALDH1A1GFERKDM4EL3MBTL1 | |
| SCHEMBL13985382 | 0.84 | SIGMAR1 (0.50) | ALDH1A1HTTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170848-B1 | PYRAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LUNG DISEASES | ASTRAZENECA AB (SE) | 2014-10-22 | — | — | EP | disclosed |