Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16185165 | 0.93 | GRM5 (0.36) | GRM5MAP4K4CHRNA7MAPTLMNA | |
| SCHEMBL16185141 | 0.92 | CHRNA7 (0.42) | GRM5CHRNA7MAPTLMNAEGFR | |
| SCHEMBL16185129 | 0.90 | MAP4K4 (0.40) | MAP4K4LMNAKITIKBKBCHUK | |
| SCHEMBL16185134 | 0.89 | FFAR1 (0.47) | GRM5MAP4K4LMNAFFAR1 | |
| SCHEMBL16185148 | 0.87 | CHRNA7 (0.37) | GRM5CHRNA7MAPTLMNAFFAR1 | |
| SCHEMBL16185155 | 0.87 | CHRNA7 (0.37) | GRM5CHRNA7MAPTLMNAFBP1 | |
| SCHEMBL16185138 | 0.86 | GRM5 (0.48) | GRM5MAP4K4CHRNA7MAPTLMNA | |
| SCHEMBL14474675 | 0.85 | KLKB1 (0.34) | GRM5MAP4K4CHRNA7LMNAFFAR1 | |
| SCHEMBL14475257 | 0.85 | GRM5 (0.35) | GRM5CHRNA7LMNAFFAR1EGFR | |
| SCHEMBL16185137 | 0.85 | GRM5 (0.46) | GRM5MAP4K4CHRNA7MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | GRM5 37/4885MAP4K4 635/4885CHRNA7 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.