Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16185156 | 0.93 | CHRNA7 (0.38) | CHRNA7SCN9AEGFRLMNAMAPT | |
| SCHEMBL14474677 | 0.91 | SCN9A (0.43) | SCN9ALMNASMN1; SMN2 | |
| SCHEMBL14475269 | 0.90 | KDM4E (0.35) | CHRNA7SCN9AEGFRLMNAMAPT | |
| SCHEMBL16185142 | 0.90 | CHRNA7 (0.42) | CHRNA7SCN9AEGFRLMNAMAPT | |
| SCHEMBL16185147 | 0.88 | FFAR1 (0.43) | CHRNA7LMNASMN1; SMN2GRM5 | |
| SCHEMBL16185166 | 0.88 | CHRNA7 (0.36) | CHRNA7SCN9AEGFRLMNAMAPT | |
| SCHEMBL14474684 | 0.87 | CHRNA7 (0.39) | CHRNA7KLKB1LMNAMAPTCASP6 | |
| SCHEMBL16185150 | 0.87 | GRM5 (0.40) | CHRNA7KLKB1EGFRLMNAMAPT | |
| SCHEMBL14474686 | 0.86 | SCN9A (0.37) | CHRNA7SCN9AKLKB1EGFRLMNA | |
| SCHEMBL14474191 | 0.86 | GRM5 (0.44) | CHRNA7SCN9AEGFRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | CHRNA7 349/4885SCN9A 3217/4885KLKB1 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.