Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 6/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 5/20 | 0.31 |
| ▸ | TESK2 | Q96S53 | 3/20 | 0.31 |
| ▸ | TESK1 | Q15569 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14474202 | 0.93 | CHRNA7 (0.45) | CHRNA7LIMK1MAPK14GRM5TSHR | |
| SCHEMBL16185137 | 0.91 | GRM5 (0.46) | CHRNA7LIMK1MAPK14GRM5KIT | |
| SCHEMBL14474187 | 0.90 | SCN9A (0.38) | LIMK1GRM5TSHRKITSCN9A | |
| SCHEMBL14474684 | 0.87 | CHRNA7 (0.39) | CHRNA7LIMK1MAPK14GRM5MAPT | |
| SCHEMBL16185157 | 0.87 | CHRNA7 (0.39) | CHRNA7LIMK1MAPK14GRM5TSHR | |
| SCHEMBL16184368 | 0.86 | GRM5 (0.38) | GRM5CYP2D6CYP2C9CYP2C19LATS1 | |
| SCHEMBL16185164 | 0.86 | GRM5 (0.43) | MAPK14GRM5LMNA | |
| SCHEMBL14475264 | 0.85 | PIM1 (0.36) | CHRNA7LIMK1MAPK14GRM5TSHR | |
| SCHEMBL16184852 | 0.85 | HSD17B10 (0.47) | GRM5TSHRCYP2D6CYP19A1CYP2C9 | |
| SCHEMBL16185166 | 0.85 | CHRNA7 (0.36) | CHRNA7GRM5KITSCN9ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | CHRNA7 349/4885LIMK1 1791/4885MAPK14 2173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.