Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 10/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.40 |
| ▸ | USP2 | O75604 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 6/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16186355 | 0.90 | KIT (0.41) | CYP1A2CYP3A4CYP2C19CLK4ALDH1A1 | |
| SCHEMBL16186295 | 0.88 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2C19CLK4ALDH1A1 | |
| SCHEMBL16184377 | 0.88 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C19CLK4ALDH1A1 | |
| SCHEMBL16184196 | 0.87 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C19CLK4ALDH1A1 | |
| SCHEMBL16184206 | 0.87 | KIT (0.40) | CYP1A2CYP3A4CYP2C19CLK4ALDH1A1 | |
| SCHEMBL16184203 | 0.86 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2C19CLK4ALDH1A1 | |
| SCHEMBL16184207 | 0.86 | MAP4K4 (0.43) | CYP1A2CYP3A4CYP2C19CLK4ALDH1A1 | |
| SCHEMBL16184183 | 0.86 | KIT (0.41) | KITBRAFABCG2SCN9A | |
| SCHEMBL16184213 | 0.82 | KIT (0.38) | CYP1A2CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL16184204 | 0.82 | SYK (0.43) | CYP1A2CYP3A4CYP2C19CLK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | CYP1A2 2971/4885CYP3A4 4456/4885CYP2C19 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.