Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.50 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2418283 | 0.88 | ACHE (0.52) | USP30BTKACHE | |
| SCHEMBL31227195 | 0.87 | PIK3CD (0.48) | USP30BTKPIM1PIM2PIK3CD | |
| SCHEMBL31227119 | 0.87 | ANO1 (0.51) | USP30BTKPIM1PIM2PIK3CD | |
| SCHEMBL31247168 | 0.87 | PIK3CD (0.48) | USP30BTKPIM1PIM2PIK3CD | |
| SCHEMBL31227554 | 0.86 | USP30 (0.48) | USP30BTKPIM1PIM2PIK3CD | |
| SCHEMBL31227846 | 0.86 | PIK3CD (0.49) | USP30BTKPIM1PIM2PIK3CD | |
| SCHEMBL31227249 | 0.85 | PIM1 (0.49) | USP30BTKPIM1PIM2PARP1 | |
| SCHEMBL31227054 | 0.85 | PIM1 (0.49) | USP30BTKPIM1PIM2PARP1 | |
| SCHEMBL31227548 | 0.85 | PIM1 (0.49) | USP30BTKPIM1PIM2PARP1 | |
| SCHEMBL31227089 | 0.85 | BTK (0.47) | USP30BTKPIM1PIM2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160058768-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160058768-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160058768-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER (US) | 2016-03-03 | — | — | US | disclosed |
| US-9227956-B2 | Substituted amide compounds | PFIZER INC. (US) | 2016-01-05 | — | — | US | disclosed |
| US-9227956-B2 | Substituted amide compounds | PFIZER INC. (US) | 2016-01-05 | — | — | US | disclosed |
| WO-2014170786-A1 | N-PIPERIDIN-3-YLBENZAMIDE DERIVATIVES FOR TREATING CARDIOVASCULAR DISEASES | PFIZER INC. (US) | 2014-10-23 | — | — | WO | disclosed |
| US-20140315928-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140315928-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315928-A1 | SUBSTITUTED AMIDE COMPOUNDS | CETP, APOB, LCAT | USP30 2477/4885BTK 871/4885ACHE 1814/4885 |
| US-20160058768-A1 | SUBSTITUTED AMIDE COMPOUNDS | CETP, APOB, LCAT | USP30 2477/4885BTK 871/4885ACHE 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.