⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133336 | 0.90 | NEK2 (0.39) | — | |
| SCHEMBL6560160 | 0.90 | OR51E2 (0.39) | — | |
| SCHEMBL9986841 | 0.89 | OR51E2 (0.34) | — | |
| SCHEMBL20633689 | 0.88 | OR51E2 (0.37) | — | |
| SCHEMBL31580458 | 0.85 | OPRM1 (0.42) | — | |
| SCHEMBL23119745 | 0.84 | GAA (0.48) | — | |
| SCHEMBL20758273 | 0.83 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL20758911 | 0.81 | GAA (0.40) | — | |
| SCHEMBL20758523 | 0.81 | CRBN (0.38) | — | |
| SCHEMBL9986510 | 0.81 | HSD11B1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230287009-A1 | OXO-SUBSTITUTED COMPOUND | Sumitomo Pharma Co., Ltd. (JP) | 2023-09-14 | — | — | US | disclosed |
| US-20230287009-A1 | OXO-SUBSTITUTED COMPOUND | Sumitomo Pharma Co., Ltd. (JP) | 2023-09-14 | — | — | US | disclosed |
| US-11702431-B2 | Oxo-substituted compound | Sumitomo Pharma Co., Ltd. (JP) | 2023-07-18 | — | — | US | disclosed |
| WO-2023280181-A1 | 1,2,4-TRIAZOLONE DERIVATIVE AS DHODH INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 微境生物医药科技(上海)有限公司 | 2023-01-12 | — | — | WO | disclosed |
| US-11459336-B2 | Pyrazine carbamates and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-10-04 | — | — | US | disclosed |
| US-20220143020-A1 | 2-AMINOQUINAZOLINONE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2022-05-12 | — | — | US | disclosed |
| US-20200392155-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | US | disclosed |
| WO-2016029839-A1 | (SUBSTITUTED PHENYL) (SUBSTITUTED PYRIMIDINE) AMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICATION USE | 四川海思科制药有限公司 | 2016-03-03 | — | — | WO | disclosed |
| WO-2014202027-A1 | SPIROCYCLIC DERIVATIVE OF 4,5-DIHYDROPYRAZOLO[3,4-C]PYRIDINE-2-ONE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 (CN) | 2014-12-24 | — | — | WO | disclosed |
| WO-2014169845-A2 | 4,5-DIHYDRO-PYRAZOLO [3, 4-C] PYRID-2-ONES, PREPARATION METHOD AND APPLICATION THEREOF | 四川海思科制药有限公司 (CN) | 2014-10-23 | — | — | WO | disclosed |