Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.42 |
| ▸ | F10 | P00742 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76589 | 0.83 | ALDH1A1 (0.45) | PARP1F10HSD17B10KDM4EGAA | |
| SCHEMBL29349011 | 0.81 | HSD17B10 (0.42) | PARP1F10HSD17B10KDM4EGAA | |
| SCHEMBL8305775 | 0.81 | HSD17B10 (0.45) | PARP1F10HSD17B10ALDH1A1AKR1C3 | |
| SCHEMBL85665 | 0.81 | ALDH1A1 (0.44) | PARP1F10HSD17B10KDM4EGAA | |
| SCHEMBL12848677 | 0.80 | HSD17B10 (0.44) | PARP1F10HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL6329653 | 0.80 | PARP1 (0.43) | PARP1F10HSD17B10KDM4EGAA | |
| SCHEMBL9360420 | 0.79 | ADRA1B (0.51) | PARP1HSD17B10KDM4EGAAALDH1A1 | |
| SCHEMBL23168572 | 0.78 | HSD17B10 (0.42) | PARP1HSD17B10KDM4EGAAALDH1A1 | |
| SCHEMBL14311448 | 0.78 | PARP1 (0.41) | PARP1F10HSD17B10KDM4EGAA | |
| SCHEMBL8136067 | 0.78 | TP53 (0.48) | F10KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105026392-B | 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof | 四川海思科制药有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-104395312-B | The Spirocyclic derivatives of 4,5-dihydro-pyrazolo [3,4-c] pyridin-2-ones, its preparation method and application | SICHUAN HAISCO PHARMACEUTICAL CO.,LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |
| WO-2014202027-A1 | SPIROCYCLIC DERIVATIVE OF 4,5-DIHYDROPYRAZOLO[3,4-C]PYRIDINE-2-ONE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 (CN) | 2014-12-24 | — | — | WO | disclosed |
| WO-2014202027-A1 | SPIROCYCLIC DERIVATIVE OF 4,5-DIHYDROPYRAZOLO[3,4-C]PYRIDINE-2-ONE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 (CN) | 2014-12-24 | — | — | WO | disclosed |
| WO-2014169845-A2 | 4,5-DIHYDRO-PYRAZOLO [3, 4-C] PYRID-2-ONES, PREPARATION METHOD AND APPLICATION THEREOF | 四川海思科制药有限公司 (CN) | 2014-10-23 | — | — | WO | disclosed |
| CN-104109165-A | 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives, and preparation method and application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2014-10-22 | — | — | CN | disclosed |