Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16180542 | 0.93 | KDM4E (0.53) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL16180543 | 0.93 | KDM4E (0.53) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL20106730 | 0.85 | MAPT (0.46) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL17576071 | 0.85 | GLA (0.45) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL16180419 | 0.82 | TUBB4A (0.54) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL16180418 | 0.82 | TUBB4A (0.54) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL20101492 | 0.81 | TUBB4A (0.47) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL1956953 | 0.80 | GLA (0.54) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL1956955 | 0.80 | GLA (0.54) | MAPTKDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL20106756 | 0.76 | TUBB4A (0.45) | MAPTKDM4ENPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118710-A1 | COMBRETASTATIN ANALOGS | BIOVENTURES, LLC | 2018-05-03 | — | — | US | disclosed |
| US-9884842-B2 | Combretastatin analogs | BIOVENTURES, LLC (US) | 2018-02-06 | — | — | US | disclosed |
| US-20160068506-A1 | COMBRETASTATIN ANALOGS | BIOVENTURES, LLC | 2016-03-10 | — | — | US | disclosed |
| WO-2014172363-A2 | COMBRETASTATIN ANALOGS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2014-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118710-A1 | COMBRETASTATIN ANALOGS | HDAC6, HDAC11, HDAC5 | MAPT 3070/4885KDM4E 2118/4885NPC1 430/4885 |
| US-20160068506-A1 | COMBRETASTATIN ANALOGS | HDAC6, HDAC11, HDAC5 | MAPT 3070/4885KDM4E 2118/4885NPC1 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.