Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.43 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.43 |
| ▸ | TUBB | P07437 | 3/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16180418 | 0.91 | TUBB4A (0.54) | GLANPC1RAB9AMAPTKDM4E | |
| SCHEMBL16180419 | 0.91 | TUBB4A (0.54) | GLANPC1RAB9AMAPTKDM4E | |
| SCHEMBL20101492 | 0.89 | TUBB4A (0.47) | GLANPC1RAB9AMAPTKDM4E | |
| SCHEMBL1956955 | 0.88 | GLA (0.54) | GLANPC1RAB9AMAPTKDM4E | |
| SCHEMBL1956953 | 0.88 | GLA (0.54) | GLANPC1RAB9AMAPTKDM4E | |
| SCHEMBL16180542 | 0.86 | KDM4E (0.53) | GLANPC1RAB9AMAPTKDM4E | |
| SCHEMBL16180543 | 0.86 | KDM4E (0.53) | GLANPC1RAB9AMAPTKDM4E | |
| SCHEMBL16190108 | 0.85 | MAPT (0.49) | GLANPC1RAB9AMAPTKDM4E | |
| SCHEMBL20106756 | 0.84 | TUBB4A (0.45) | NPC1RAB9AMAPTKDM4EPOLB | |
| SCHEMBL20106730 | 0.80 | MAPT (0.46) | GLANPC1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118710-A1 | COMBRETASTATIN ANALOGS | BIOVENTURES, LLC | 2018-05-03 | — | — | US | disclosed |
| US-9884842-B2 | Combretastatin analogs | BIOVENTURES, LLC (US) | 2018-02-06 | — | — | US | disclosed |
| US-20160068506-A1 | COMBRETASTATIN ANALOGS | BIOVENTURES, LLC | 2016-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118710-A1 | COMBRETASTATIN ANALOGS | HDAC6, HDAC11, HDAC5 | GLA 458/4885NPC1 430/4885RAB9A 544/4885 |
| US-20160068506-A1 | COMBRETASTATIN ANALOGS | HDAC6, HDAC11, HDAC5 | GLA 458/4885NPC1 430/4885RAB9A 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.