Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.47 |
| ▸ | LATS1 | O95835 | 11/20 | 0.42 |
| ▸ | LATS2 | Q9NRM7 | 5/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14975882 | 0.78 | PRKCI (0.55) | PRKCILATS1LATS2CYP2A6 | |
| SCHEMBL23348877 | 0.73 | LATS1 (0.51) | PRKCILATS1LATS2CLK4NFATC1 | |
| SCHEMBL577965 | 0.68 | KDM4E (0.47) | ALDH1A1CYP1A2LMNAMAPK1 | |
| SCHEMBL31301252 | 0.65 | GSK3B (0.59) | LATS1LATS2CYP3A4CLK4NFATC1 | |
| SCHEMBL7493404 | 0.65 | ADORA2A (0.37) | TSHR | |
| SCHEMBL1093728 | 0.64 | PIK3CA (0.50) | PRKCICYP2A6CTSA | |
| SCHEMBL28457549 | 0.63 | LATS1 (0.43) | PRKCILATS1LATS2ALDH1A1CYP1A2 | |
| SCHEMBL14975058 | 0.61 | PRKCI (0.57) | PRKCILATS1LATS2 | |
| SCHEMBL14104062 | 0.61 | MEN1 (0.55) | PRKCIUSP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31375786 | 0.60 | LATS1 (0.67) | LATS1LATS2USP2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604994-B2 | Thienopyrimidine inhibitors of atypical protein kinase C | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2017-03-28 | — | — | US | disclosed |
| US-20140323435-A1 | Thienopyrimidine Inhibitors of Atypical Protein Kinase C | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323435-A1 | Thienopyrimidine Inhibitors of Atypical Protein Kinase C | PRKCQ, PRKDC, PRKACA | PRKCI 12/4885LATS1 1058/4885LATS2 1468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.