Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491775 | 0.77 | ADORA2A (0.44) | ADORA2AADORA1 | |
| SCHEMBL7494497 | 0.74 | ADORA2A (0.36) | ADORA2AADORA1 | |
| SCHEMBL7486631 | 0.70 | PDE4A (0.41) | — | |
| SCHEMBL5926130 | 0.69 | ADORA2A (0.31) | ADORA2AADORA1 | |
| SCHEMBL577965 | 0.69 | KDM4E (0.47) | ADORA2AADORA1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL61008 | 0.64 | ADORA2A (0.49) | ADORA2AADORA1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1601774 | 0.64 | — | — | |
| SCHEMBL857662 | 0.64 | LMNA (0.39) | HPGDPOLB | |
| SCHEMBL16863968 | 0.63 | ADORA2A (0.44) | ADORA2AADORA1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2162809 | 0.62 | KDM4E (0.41) | ADORA2AADORA1NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915093-B1 | AMIDE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-11-27 | — | — | EP | disclosed |
| US-6166016-A | Amide derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0915093-A1 | AMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-05-12 | — | — | EP | disclosed |