Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 16/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16208530 | 0.85 | SIGMAR1 (0.61) | SIGMAR1 | |
| SCHEMBL16208503 | 0.77 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL16197800 | 0.74 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL16208514 | 0.74 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL16197294 | 0.72 | SIGMAR1 (0.61) | SIGMAR1 | |
| SCHEMBL17583772 | 0.70 | SIGMAR1 (0.47) | SIGMAR1 | |
| SCHEMBL16197459 | 0.70 | SIGMAR1 (0.66) | SIGMAR1 | |
| SCHEMBL16197277 | 0.68 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL16197643 | 0.68 | SIGMAR1 (0.70) | SIGMAR1 | |
| SCHEMBL16197983 | 0.68 | SIGMAR1 (1.00) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2989104-B1 | PYRAZINO[1,2-A]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS SA (ES) | 2019-08-21 | — | — | EP | claimed |
| US-9963453-B2 | Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-05-08 | — | — | US | claimed |
| US-20160075709-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2016-03-17 | — | — | US | claimed |
| EP-2989104-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2016-03-02 | — | — | EP | claimed |
| WO-2014173901-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-10-30 | — | — | WO | claimed |
| EP-2989104-B1 | PYRAZINO[1,2-A]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS SA (ES) | 2019-08-21 | — | — | EP | disclosed |
| EP-2989104-B1 | PYRAZINO[1,2-A]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS SA (ES) | 2019-08-21 | — | — | EP | disclosed |
| US-9963453-B2 | Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-05-08 | — | — | US | disclosed |
| US-9963453-B2 | Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-05-08 | — | — | US | disclosed |
| US-9963453-B2 | Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-05-08 | — | — | US | disclosed |
| US-20160075709-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2016-03-17 | — | — | US | disclosed |
| US-20160075709-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2016-03-17 | — | — | US | disclosed |
| EP-2989104-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2016-03-02 | — | — | EP | disclosed |
| WO-2014173901-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075709-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | IDO1, TPH1, IDO2 | SIGMAR1 168/4885THRB 1538/4885ALDH1A1 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.