Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.70 |
| ▸ | PORCN | Q9H237 | 4/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | GALR3 | O60755 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | NAMPT | P43490 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.55 |
| ▸ | WNT3A | P56704 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16198579 | 0.88 | LMNA (0.76) | NOTUMPORCNCYP3A4CYP2D6GALR3 | |
| SCHEMBL16198217 | 0.85 | PORCN (0.84) | NOTUMPORCNCYP3A4CYP2D6GALR3 | |
| SCHEMBL4527479 | 0.84 | LMNA (0.83) | NOTUMPORCNCYP3A4CYP2D6GALR3 | |
| SCHEMBL31121893 | 0.82 | NOTUM (1.00) | NOTUMGALR3RAB9ATDP1LMNA | |
| SCHEMBL15785422 | 0.82 | CYP3A4 (0.59) | NOTUMCYP3A4CYP2D6KMT2AMKNK2 | |
| SCHEMBL16197628 | 0.81 | PORCN (0.64) | NOTUMPORCNCYP3A4CYP2D6GALR3 | |
| SCHEMBL1790136 | 0.81 | MKNK2 (0.67) | NOTUMPORCNGALR3RAB9ATDP1 | |
| SCHEMBL1787958 | 0.81 | MKNK2 (0.66) | NOTUMLMNAKMT2AMKNK2MKNK1 | |
| SCHEMBL16198026 | 0.81 | PORCN (0.62) | NOTUMPORCNCYP3A4CYP2D6GALR3 | |
| SCHEMBL16197884 | 0.81 | PORCN (1.00) | NOTUMPORCNCYP3A4CYP2D6GALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014175832-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-10-30 | — | — | WO | disclosed |
| WO-2014175832-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-10-30 | — | — | WO | disclosed |