Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.35 |
| ▸ | RORC | P51449 | 4/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16233283 | 1.00 | JAK1 (0.43) | JAK1NR1H2EPHX2GPR119RORC | |
| SCHEMBL16192117 | 0.83 | VDR (0.33) | — | |
| SCHEMBL20466988 | 0.82 | EPHX2 (0.36) | JAK1NR1H2EPHX2GPR119RORC | |
| SCHEMBL16233317 | 0.82 | JAK1 (0.48) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL21774462 | 0.82 | JAK1 (0.48) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL21774461 | 0.82 | JAK1 (0.48) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL25504041 | 0.82 | JAK1 (0.48) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL30402248 | 0.80 | JAK1 (0.47) | JAK1NR1H2EPHX2RORCUSP2 | |
| SCHEMBL24575156 | 0.78 | JAK1 (0.49) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL30382336 | 0.78 | JAK1 (0.49) | JAK1NR1H2EPHX2RORCCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796460-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |