Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.35 |
| ▸ | RORC | P51449 | 4/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16199575 | 1.00 | JAK1 (0.43) | JAK1NR1H2EPHX2GPR119RORC | |
| SCHEMBL16192117 | 0.83 | VDR (0.33) | — | |
| SCHEMBL20466988 | 0.82 | EPHX2 (0.36) | JAK1NR1H2EPHX2GPR119RORC | |
| SCHEMBL16233317 | 0.82 | JAK1 (0.48) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL21774462 | 0.82 | JAK1 (0.48) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL21774461 | 0.82 | JAK1 (0.48) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL25504041 | 0.82 | JAK1 (0.48) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL30402248 | 0.80 | JAK1 (0.47) | JAK1NR1H2EPHX2RORCUSP2 | |
| SCHEMBL24575156 | 0.78 | JAK1 (0.49) | JAK1NR1H2EPHX2RORCCHRM2 | |
| SCHEMBL30382336 | 0.78 | JAK1 (0.49) | JAK1NR1H2EPHX2RORCCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-02-16 | — | — | US | disclosed |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-02-16 | — | — | US | disclosed |
| US-9527851-B2 | Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2016-12-27 | — | — | US | disclosed |
| US-9527851-B2 | Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2016-12-27 | — | — | US | disclosed |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2014-11-13 | — | — | US | disclosed |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | DHFR, PPOX, PAH | JAK1 1695/4885NR1H2 3474/4885EPHX2 808/4885 |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JAK2, JAK1, JAK3 | JAK1 2/4885NR1H2 4511/4885EPHX2 3122/4885 |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JAK1, JAK3, JAK2 | JAK1 1/4885NR1H2 3663/4885EPHX2 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.