Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3082147 | 0.89 | MET (0.47) | METLSSKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13152979 | 0.89 | MET (0.47) | METLSSKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12547150 | 0.84 | MET (0.47) | METLSSKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1301780 | 0.79 | MET (0.56) | METLSSKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3102033 | 0.78 | MET (0.52) | METLSSKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3740603 | 0.78 | MET (0.52) | METLSSKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1317864 | 0.76 | MET (0.52) | METLSSKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1316603 | 0.75 | CHEK2 (0.52) | METLSSKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3091899 | 0.71 | MET (0.69) | MET | |
| SCHEMBL3098308 | 0.71 | MET (0.69) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164843-B1 | PYRIDAZINONE DERIVATES | MERCK PATENT GMBH (DE) | 2014-10-29 | — | — | EP | disclosed |