Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.52 |
| ▸ | MET | P08581 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3740603 | 0.82 | MET (0.52) | METKDM4EALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL3102033 | 0.82 | MET (0.52) | CHEK2METKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1317864 | 0.80 | MET (0.52) | CHEK2METKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1301780 | 0.78 | MET (0.56) | CHEK2METKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2474804 | 0.78 | MET (0.68) | MET | |
| SCHEMBL13152979 | 0.76 | MET (0.47) | CHEK2METKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12547150 | 0.76 | MET (0.47) | CHEK2METKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3082147 | 0.76 | MET (0.47) | CHEK2METKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1551661 | 0.76 | CHEK2 (0.69) | CHEK2DYRK3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL16199801 | 0.75 | MET (0.46) | CHEK2METKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376426-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-8853211-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
| US-20110269765-A1 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MET, RET, ERBB2 | CHEK2 105/4885MET 1/4885KDM4E 1247/4885 |
| US-20110269765-A1 | Pyridazinone derivatives | MET, RET, ERBB2 | CHEK2 105/4885MET 1/4885KDM4E 1247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.