Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SLC34A1 | Q06495 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996558 | 0.85 | ALDH1A1 (0.52) | THRBNPSR1TDP1MAPTLMNA | |
| SCHEMBL14996629 | 0.85 | NR1H2 (0.44) | THRBRECQLNPSR1MAPTLMNA | |
| SCHEMBL16200055 | 0.83 | MAPK14 (0.43) | THRBNPSR1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13736647 | 0.82 | RECQL (0.51) | RECQLNPSR1TDP1MAPTLMNA | |
| SCHEMBL14996607 | 0.81 | TSHR (0.42) | THRBNPSR1TDP1MAPTLMNA | |
| SCHEMBL16200063 | 0.81 | ALDH1A1 (0.48) | THRBHSD17B10ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL14996608 | 0.80 | MAPT (0.47) | THRBRECQLNPSR1TDP1MAPT | |
| SCHEMBL13858455 | 0.79 | MAPT (0.51) | RECQLNPSR1TDP1MAPTLMNA | |
| SCHEMBL26617161 | 0.79 | RECQL (0.49) | RECQLNPSR1TDP1MAPTLMNA | |
| SCHEMBL13738541 | 0.79 | TDP1 (0.51) | THRBRECQLNPSR1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4273147-A1 | SUBSTITUTED SPIROLACTAMS, SALTS THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES | Bayer Aktiengesellschaft (DE) | 2023-11-08 | — | — | EP | disclosed |
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |