Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875478 | 0.85 | NOTUM (0.41) | MAPTGAATP53CYP1A2CYP3A4 | |
| SCHEMBL2873737 | 0.85 | MAPK1 (0.40) | MAPTGAATP53CYP1A2CYP3A4 | |
| SCHEMBL2870930 | 0.83 | GAA (0.41) | MAPTGAATP53CYP1A2CYP3A4 | |
| SCHEMBL2873684 | 0.83 | ENPP1 (0.44) | MAPTCYP1A2CYP2C9MAPK1CYP2C19 | |
| SCHEMBL8593143 | 0.77 | NPSR1 (0.43) | MAPTLMNAMEN1KMT2ANPSR1 | |
| SCHEMBL28724767 | 0.76 | GAA (0.44) | MAPTGAACYP1A2CYP2C9MAPK1 | |
| SCHEMBL2876798 | 0.73 | NT5E (0.42) | MAPTTP53MAPK1LMNASMN1; SMN2 | |
| SCHEMBL16200084 | 0.73 | CYP2A6 (0.41) | CYP1A2CYP3A4SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL8196073 | 0.71 | ENPP1 (0.35) | MAPK1LMNAPIK3CDPIK3CAPIK3CB | |
| SCHEMBL6548270 | 0.71 | PTGS2 (0.51) | CYP3A4CYP2D6CYP2C9LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |