Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357745 | 0.77 | KDM4E (0.43) | KDM4EGLSALDH1A1SMN1; SMN2ADORA2A | |
| SCHEMBL7981164 | 0.77 | KDM4E (0.43) | KDM4EGLSALDH1A1SMN1; SMN2ADORA2A | |
| SCHEMBL13066525 | 0.75 | KDM4E (0.46) | KDM4EGLSALDH1A1SMN1; SMN2ADORA2A | |
| SCHEMBL13184316 | 0.75 | KDM4E (0.46) | KDM4EGLSALDH1A1SMN1; SMN2ADORA2A | |
| SCHEMBL4352330 | 0.69 | KDM4E (0.49) | KDM4EGLSALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16200059 | 0.68 | NMT1 (0.34) | GLSALDH1A1LMNABPTF | |
| SCHEMBL13066523 | 0.67 | SIGMAR1 (0.40) | KDM4EALDH1A1LMNA | |
| SCHEMBL16307582 | 0.67 | SMN1; SMN2 (0.49) | KDM4EALDH1A1SMN1; SMN2LMNAGALR3 | |
| SCHEMBL1196791 | 0.66 | — | — | |
| SCHEMBL1086373 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |