Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454847 | 0.77 | CDC7 (0.49) | NOTUMNR1H2NR1H3DCUN1D1DYRK1A | |
| SCHEMBL2876858 | 0.77 | AKT2 (0.50) | GAASMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL13024563 | 0.76 | GAA (0.55) | ADORA2AADORA1NOTUMNR1H2NR1H3 | |
| SCHEMBL24765276 | 0.75 | CHEK1 (0.59) | NOTUMNR1H2NR1H3DCUN1D1DYRK1A | |
| SCHEMBL8036864 | 0.74 | NR1H2 (0.51) | ADORA2AADORA1NOTUMNR1H2NR1H3 | |
| SCHEMBL8623261 | 0.71 | MAPT (0.46) | ADORA2ANOTUMNR1H2NR1H3DCUN1D1 | |
| SCHEMBL13426462 | 0.70 | MAPT (0.61) | NOTUMNR1H2NR1H3DCUN1D1DYRK1A | |
| SCHEMBL17413462 | 0.70 | NOTUM (0.54) | NOTUMNR1H2NR1H3DCUN1D1DYRK1A | |
| SCHEMBL29489425 | 0.70 | CYP3A4 (0.73) | NOTUMDYRK1ACLK4GAAXDH | |
| SCHEMBL196765 | 0.70 | CYP3A4 (0.73) | NOTUMDYRK1ACLK4GAAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |