SCHEMBL8623261

SCHEMBL8623261

COc1cccc(-c2[nH]nc(-c3ccc(F)cc3)c2C)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.46
TP53 P04637 1/20 0.46
GAA P10253 1/20 0.46
DCUN1D1 Q96GG9 1/20 0.45
ALDH1A3 P47895 2/20 0.44
NPY5R Q15761 1/20 0.44
DYRK1A Q13627 2/20 0.44
DYRK1B Q9Y463 2/20 0.44
SQOR Q9Y6N5 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
ADORA2A P29274 1/20 0.42
NOTUM Q6P988 1/20 0.42
NR1H2 P55055 1/20 0.42
NR1H3 Q13133 1/20 0.42
XDH P47989 1/20 0.42
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
USP2 O75604 1/20 0.41
ALOX15 P16050 1/20 0.41
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17279998 0.85 CDK4 (0.50) MAPTTP53GAAMEN1NPC1
SCHEMBL17279834 0.75 ALDH1A1 (0.50) MAPTTP53GAADYRK1ASMN1; SMN2
SCHEMBL24314980 0.75 ALDH1A3 (0.58) MAPTALDH1A3NPY5RDYRK1ASQOR
SCHEMBL30610970 0.75 ALDH1A3 (0.58) MAPTALDH1A3NPY5RDYRK1ASQOR
SCHEMBL1608239 0.73 NPC1 (0.64) MAPTTP53GAAALDH1A3SMN1; SMN2
SCHEMBL15117074 0.72 NR1H2 (0.80) MAPTTP53DCUN1D1ALDH1A3DYRK1A
SCHEMBL4736181 0.71 NTRK1 (0.56) DYRK1AMEN1NPC1USP2ALOX15
SCHEMBL16200082 0.71 ADORA2A (0.47) MAPTGAADCUN1D1DYRK1ADYRK1B
SCHEMBL11362250 0.69 KDM4E (0.60) MAPTTP53GAASMN1; SMN2NPC1
SCHEMBL1548731 0.69 KDM4E (0.60) MAPTTP53GAASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0843665-A1 METHOD OF PREPARING 1,2-DIMETHYL-3,5-DIARYLPYRAZOLIUM METHYLSULPHATES BASF AKTIENGESELLSCHAFT (DE) 1998-05-27 EP disclosed
WO-1997006148-A1 METHOD OF PREPARING 1,2-DIMETHYL-3,5-DIARYLPYRAZOLIUM METHYLSULPHATES BASF AKTIENGESELLSCHAFT (DE) 1997-02-20 WO disclosed