Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | AKT2 | P31751 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19992722 | 0.82 | AKT2 (0.53) | CHEK1AKT2ROCK2ROCK1DYRK1A | |
| SCHEMBL3262839 | 0.80 | MAPT (0.49) | ROCK2ROCK1SMN1; SMN2LMNAATM | |
| SCHEMBL13035810 | 0.80 | AKT2 (0.67) | CHEK1AKT2LMNANOTUMIKBKE | |
| SCHEMBL5454847 | 0.77 | CDC7 (0.49) | ROCK2NOTUMNR1H2NR1H3DCUN1D1 | |
| SCHEMBL30829475 | 0.77 | AKT2 (0.62) | CHEK1AKT2SMN1; SMN2NOTUMMAPT | |
| SCHEMBL26832622 | 0.77 | AKT2 (0.62) | CHEK1AKT2ROCK2ROCK1IKBKE | |
| SCHEMBL20213984 | 0.77 | AKT2 (0.62) | CHEK1AKT2SMN1; SMN2NOTUMMAPT | |
| SCHEMBL16115987 | 0.77 | IKBKB (0.71) | CHEK1AKT2SMN1; SMN2DCUN1D1GAA | |
| SCHEMBL16474765 | 0.77 | ROCK2 (0.48) | CHEK1AKT2ROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL13426462 | 0.75 | MAPT (0.61) | SMN1; SMN2NOTUMNR1H2NR1H3DCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4169904-A1 | SUBSTITUTED QUINOLINES AS IMPROVED NF-KB-INDUCING KINASE (NIK) INHIBITORS | Yukin Therapeutics (FR) | 2023-04-26 | — | — | EP | disclosed |
| WO-2022253220-A1 | DINUCLEAR PLATINUM EMITTER COMPLEXES AND METHODS OF MAKING AND USING THEREOF | VERSITECH LIMITED (CN) | 2022-12-08 | — | — | WO | disclosed |