Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29775469 | 0.82 | LMNA (0.52) | LMNATSHRHSD17B10L3MBTL1MAPT | |
| SCHEMBL23326296 | 0.82 | LMNA (0.52) | LMNATSHRHSD17B10L3MBTL1MAPT | |
| SCHEMBL4472996 | 0.78 | TSHR (0.46) | LMNATSHRHSD17B10ALDH1A1GAA | |
| SCHEMBL23326208 | 0.78 | HTR2A (0.51) | LMNATSHRHSD17B10HTR2AHTR2C | |
| SCHEMBL7893305 | 0.78 | ALDH1A1 (0.43) | LMNATSHRHSD17B10ALDH1A1GAA | |
| SCHEMBL7797921 | 0.77 | TSHR (0.54) | LMNATSHRHSD17B10ALDH1A1GAA | |
| SCHEMBL10967724 | 0.77 | LMNA (0.57) | LMNATSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL8407819 | 0.76 | ALDH1A1 (0.45) | LMNATSHRHSD17B10ALDH1A1GAA | |
| SCHEMBL14292894 | 0.76 | KDM1A (0.39) | — | |
| SCHEMBL9954912 | 0.76 | HTR2A (0.49) | ALDH1A1HTR2AHTR2CTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |