Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852678 | 0.87 | GAA (0.56) | GAAHTTPOLBHPGDKDM4E | |
| SCHEMBL29127993 | 0.87 | GAA (0.53) | GAAHTTPOLBHPGDKDM4E | |
| SCHEMBL13469255 | 0.86 | KDM4E (0.59) | GAAHTTPOLBHPGDKDM4E | |
| SCHEMBL20445888 | 0.85 | TAAR1 (0.45) | GAAHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16200096 | 0.85 | MRGPRX4 (0.46) | GAAHTTHPGDKDM4EALDH1A1 | |
| SCHEMBL13469256 | 0.85 | KDM4E (0.46) | GAAHTTPOLBHPGDKDM4E | |
| SCHEMBL11068304 | 0.84 | TAAR1 (0.50) | GAAHTTPOLBKDM4ETAAR1 | |
| SCHEMBL8900419 | 0.82 | GAA (0.72) | GAAHTTPOLBHPGDKDM4E | |
| SCHEMBL2476221 | 0.82 | GAA (0.62) | GAAHTTPOLBHPGDKDM4E | |
| SCHEMBL20507795 | 0.81 | HPGDS (0.44) | GAAALDH1A1SMN1; SMN2TAAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |