Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189899 | 0.86 | KDM4E (0.49) | MRGPRX4KDM4ELCKFYNALDH1A1 | |
| SCHEMBL20445888 | 0.86 | TAAR1 (0.45) | TAAR1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13469242 | 0.85 | LCK (0.58) | KDM4ELCKFYNALDH1A1MEN1 | |
| SCHEMBL16200097 | 0.85 | GAA (0.55) | TAAR1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13469246 | 0.84 | MAPT (0.49) | KDM4ELCKFYNALDH1A1MEN1 | |
| SCHEMBL18309197 | 0.84 | KDM4E (0.53) | TAAR1KDM4ELCKFYNALDH1A1 | |
| SCHEMBL20507795 | 0.82 | HPGDS (0.44) | TAAR1ALDH1A1SMN1; SMN2KCNH2GAA | |
| SCHEMBL3617721 | 0.82 | ALDH1A1 (0.55) | MRGPRX4KDM4ELCKFYNALDH1A1 | |
| SCHEMBL2730020 | 0.82 | ALDH1A1 (0.49) | MRGPRX4KDM4ELCKFYNALDH1A1 | |
| SCHEMBL13244501 | 0.81 | GABRP (0.47) | TAAR1KDM4EALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |