Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184338 | 0.78 | RAB9A (0.39) | RAB9ANPC1MAPTSMN1; SMN2ATM | |
| SCHEMBL13683025 | 0.71 | RAB9A (0.42) | RAB9ANPC1MAPTSMN1; SMN2ATM | |
| SCHEMBL14044116 | 0.71 | NOTUM (0.42) | RAB9ANPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL25552106 | 0.69 | MAPT (0.43) | RAB9ANPC1MAPTSMN1; SMN2ATM | |
| SCHEMBL16202101 | 0.68 | RAB9A (0.55) | RAB9ANPC1MAPTSMN1; SMN2ATM | |
| SCHEMBL2615993 | 0.67 | MAPT (0.52) | RAB9ANPC1MAPTSMN1; SMN2ATM | |
| SCHEMBL16202103 | 0.67 | MAPT (0.47) | RAB9ANPC1MAPTSMN1; SMN2ATM | |
| SCHEMBL2615994 | 0.66 | HTT (0.56) | RAB9ANPC1MAPTSMN1; SMN2ATM | |
| SCHEMBL22041234 | 0.66 | HTT (0.44) | RAB9ANPC1MAPTSMN1; SMN2ATM | |
| SCHEMBL2615992 | 0.66 | NOTUM (0.51) | RAB9ANPC1MAPTSMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |