Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200338 | 0.80 | POLB (0.34) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13683141 | 0.79 | ALDH1A1 (0.32) | ALDH1A1POLB | |
| SCHEMBL13683020 | 0.79 | PRMT6 (0.43) | RAB9AMAPTNPC1KDM4EHTT | |
| SCHEMBL13184337 | 0.79 | MAPT (0.42) | RAB9AMAPTNPC1SMN1; SMN2ATM | |
| SCHEMBL13683019 | 0.74 | NOTUM (0.43) | POLB | |
| SCHEMBL13683028 | 0.74 | ADORA2A (0.44) | MAPTNPC1ALDH1A1GAAKDM4E | |
| SCHEMBL16200213 | 0.71 | RAB9A (0.42) | RAB9AMAPTNPC1SMN1; SMN2ATM | |
| SCHEMBL13683119 | 0.70 | ADORA2A (0.35) | SMN1; SMN2ATMALDH1A1KDM4EADORA2A | |
| SCHEMBL16200121 | 0.67 | CYP3A4 (0.38) | MAPTATML3MBTL1ALDH1A1HPGD | |
| SCHEMBL13683029 | 0.67 | PDE3B (0.36) | ALDH1A1GAAHPGDTHRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |