Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14015694 | 0.84 | CA1 (0.47) | CA1CA2CA4CA9MAPT | |
| SCHEMBL2874425 | 0.78 | CCR1 (0.51) | MAPTALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL21607521 | 0.76 | CYP19A1 (0.56) | CA1CA2CA4CA9MAPT | |
| SCHEMBL2876509 | 0.73 | KMT2A (0.56) | CA1CA2CA4CA9MAPT | |
| SCHEMBL16200398 | 0.73 | KMT2A (0.56) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL21607462 | 0.73 | ELANE (0.43) | MAPTKMT2APDE4APDE4BPDE4C | |
| SCHEMBL21607517 | 0.72 | ELANE (0.43) | MAPTALDH1A1KMT2APDE4APDE4B | |
| SCHEMBL21605710 | 0.72 | RORC (0.42) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3280613 | 0.72 | CNR2 (0.64) | MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL21607569 | 0.71 | ELANE (0.42) | MAPTKMT2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |