Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200219 | 0.84 | CA1 (0.48) | CA1CA2CA4CA9MAPT | |
| SCHEMBL14015671 | 0.80 | MAPT (0.45) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL4416586 | 0.74 | ALDH1A1 (0.62) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL14015690 | 0.74 | KMT2A (0.54) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL2876509 | 0.71 | KMT2A (0.56) | CA1CA2CA4CA9MAPT | |
| SCHEMBL3280613 | 0.70 | CNR2 (0.64) | MAPTKDM4EKMT2AMAPK1 | |
| SCHEMBL9586920 | 0.68 | ALDH1A1 (0.52) | CA1CA2CA4CA9MAPT | |
| SCHEMBL2874452 | 0.68 | KMT2A (0.57) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL13174891 | 0.68 | ERCC1 (0.50) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL20656274 | 0.67 | NPC1 (0.47) | MAPTALDH1A1KDM4EKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449576-B1 | potent antagonists of the CCR1 receptor; inflammation; (5-Chloro-2-piperazin-1-yl-phenyl)-phenyl-methanone | CHEMOCENTRYX, INC. (US) | 2008-11-11 | — | — | US | disclosed |