Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.44 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | CCR8 | P51685 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200347 | 0.83 | METAP1 (0.43) | METAP1GRM5KDM4ENPC1LMNA | |
| SCHEMBL13683155 | 0.81 | ADCY10 (0.36) | ADCY10SMN1; SMN2RECQL | |
| SCHEMBL13184354 | 0.80 | KDM4E (0.43) | METAP1GRM5KDM4ENPC1LMNA | |
| SCHEMBL13430363 | 0.78 | KDM4E (0.45) | METAP1GRM5KDM4ENPC1LMNA | |
| SCHEMBL16200177 | 0.77 | CA1 (0.43) | METAP1GRM5KDM4ENPC1LMNA | |
| SCHEMBL2686947 | 0.76 | LRRK2 (0.41) | METAP1GRM5KDM4ENPC1LMNA | |
| SCHEMBL13682912 | 0.73 | NPC1 (0.41) | METAP1GRM5KDM4ENPC1LMNA | |
| SCHEMBL16200369 | 0.70 | KMT2A (0.37) | METAP1GRM5KDM4ENPC1LMNA | |
| SCHEMBL16200049 | 0.69 | ADORA2A (0.49) | METAP1KDM4ENPC1LMNAPOLB | |
| SCHEMBL14043989 | 0.69 | ADORA1 (0.44) | METAP1METAP2NPSR1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |