Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 3/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.32 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16201187 | 0.89 | PRMT1 (0.43) | PRMT1SCN5APIK3CDPIK3CAPIK3CB | |
| SCHEMBL16201419 | 0.88 | MEN1 (0.41) | RAB9ASMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL16201361 | 0.85 | PRMT6 (0.45) | PRMT1SCN5APRMT6SCN9ACACNA2D1 | |
| SCHEMBL16201339 | 0.85 | PRMT6 (0.38) | PRMT1PRMT6PRMT8PRMT3CARM1 | |
| SCHEMBL16201438 | 0.84 | NR1I2 (0.38) | PRMT1PRMT6PRMT8PRMT3CARM1 | |
| SCHEMBL16201414 | 0.84 | PRMT1 (0.41) | PRMT1PRMT6PRMT8PRMT3CARM1 | |
| SCHEMBL16201430 | 0.82 | CYP19A1 (0.40) | CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL16201317 | 0.82 | KDM4E (0.34) | LMNA | |
| SCHEMBL16201345 | 0.82 | PRMT3 (0.40) | PRMT1SCN5APRMT6PRMT8PRMT3 | |
| SCHEMBL16201453 | 0.82 | SCN9A (0.38) | SCN9ACACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776972-B2 | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof | EPIZYME INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9346761-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20160137609-A1 | PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-05-19 | — | — | US | disclosed |
| US-20140323537-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323537-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | PRMT1 1/4885SCN5A 3019/4885PIK3CD 3639/4885 |
| US-20160137609-A1 | PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | PRMT1 1/4885SCN5A 3008/4885PIK3CD 3171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.