Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 4/20 | 0.32 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.32 |
| ▸ | NMT1 | P30419 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 2/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16201296 | 0.90 | PRMT6 (0.44) | KDM5APRMT6PRMT8CARM1PRMT1 | |
| SCHEMBL16201407 | 0.86 | KDM5A (0.34) | KDM5APRMT6PRMT8CARM1PRMT1 | |
| SCHEMBL16201382 | 0.82 | SMN1; SMN2 (0.41) | PRMT6PRMT8CARM1PRMT1PRMT3 | |
| SCHEMBL16201446 | 0.82 | PRMT6 (0.42) | KDM5APRMT6PRMT8CARM1PRMT1 | |
| SCHEMBL16201373 | 0.81 | STK4 (0.44) | PRMT6PRMT8CARM1PRMT1LMNA | |
| SCHEMBL16201410 | 0.81 | NOTUM (0.38) | PRMT6PRMT8CARM1PRMT1PRMT3 | |
| SCHEMBL16201329 | 0.81 | NPC1 (0.44) | PRMT6PRMT8CARM1PRMT1PRMT3 | |
| SCHEMBL16201459 | 0.81 | PRMT6 (0.33) | PRMT6PRMT8CARM1PRMT1PRMT3 | |
| SCHEMBL16201341 | 0.80 | MOK (0.37) | PRMT6PRMT8CARM1PRMT1PRMT3 | |
| SCHEMBL16201387 | 0.80 | GAA (0.41) | LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776972-B2 | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof | EPIZYME INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9346761-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20160137609-A1 | PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-05-19 | — | — | US | disclosed |
| US-20140323537-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323537-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | KDM5A 102/4885CTSS 3994/4885CTSK 3767/4885 |
| US-20160137609-A1 | PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | KDM5A 123/4885CTSS 4218/4885CTSK 3563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.